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Cat. No.	Product Name	Target	Signaling Pathways
T23094	NTNCB hydrochloride	Others; Neuropeptide Y Receptor	GPCR/G Protein; Neuroscience; Others
	NTNCB hydrochloride 是一种神经肽 Y Y5 受体的拮抗剂。
T8963	CYM2503	Neuropeptide Y Receptor	GPCR/G Protein; Neuroscience
	CYM2503 是 GAL2 受体的正变构调节剂 (PAM)，可在体外增强甘丙肽诱导的 IP1 产生。它对受体的正构甘丙肽结合位点没有亲和力（通过其无法置换碘化甘丙肽或自行诱导 IP1 积累来衡量）。
TQ0286	MK-0557	Neuropeptide Y Receptor	GPCR/G Protein; Neuroscience
	MK-0557 是神经肽 Y5 受体的选择性口服拮抗剂，Ki 值为1.6 nM。
TP2206	[Leu31,Pro34]-Neuropeptide Y (porcine) LEU 31, PRO34]-神经肽Y(猪)	Neuropeptide Y Receptor	GPCR/G Protein; Neuroscience
	[Leu31,Pro34]- Neuropeptide Y (porcine) 是神经肽 Y (NPY) 的一种类似物，是对NPY Y1受体有选择性的激动作用。它表现出抗焦虑作用。
TP1380	Galanin (1-16), mouse, porcine, rat	Neuropeptide Y Receptor	GPCR/G Protein; Neuroscience
	Galanin (1-16), mouse, porcine, rat 是一种有效的甘丙肽受体激动剂，Kd 为 3 nM。
T17222	Velneperit 韦利贝特,S2367	Neuropeptide Y Receptor	GPCR/G Protein; Neuroscience
	Velneperit (S2367) 是一种有效且选择性的神经肽 Y (NPY) Y5 受体，有用于治疗肥胖症的研究潜力。
T10539	BIBO3304 TFA	Neuropeptide Y Receptor	GPCR/G Protein; Neuroscience
	BIBO3304 TFA 是一种可口服的、选择性的神经肽 Y(NPY) Y1受体高效拮抗剂，对人和大鼠 Y1 受体均具有高亲和力，IC50分别为 0.38 和 0.72 nM。
T5587	CGP71683 hydrochloride CGP71683A,盐酸CGP71683	Neuropeptide Y Receptor	GPCR/G Protein; Neuroscience
	CGP71683 hydrochloride (CGP71683A) 是竞争性的神经肽受体拮抗剂，Ki 值为 1.3 nM。
T1997	JNJ-31020028 JNJ 31020028	Neuropeptide Y Receptor	GPCR/G Protein; Neuroscience
	JNJ-31020028是神经肽Y2受体选择性可脑渗透抑制剂，对人Y2和鼠源Y2受体pIC50值分别为8.07和8.22，其神经肽 Y2 受体的选择性比人 Y1/Y4/Y5 受体高 100 倍。
T5455	HT-2157 SNAP37889,SNAP-37889	Neuropeptide Y Receptor	GPCR/G Protein; Neuroscience
	HT-2157 (SNAP-37889) 是一种高亲和力、选择性和竞争性的甘丙肽 3 受体 (Gal3) 拮抗剂。
TP1059	Peptide YY (PYY) (3-36), human Peptide YY (3-36)	Neuropeptide Y Receptor	GPCR/G Protein; Neuroscience
	Peptide YY (PYY) (3-36), human (Peptide YY (3-36)) 是一种肠胃激素肽，可以激动Y2受体，具有降低食欲的功效。
T8456	GALNON	Neuropeptide Y Receptor	GPCR/G Protein; Neuroscience
	Galnon 是一种甘丙肽受体激动剂，可改善内在的皮质骨组织特性。
T12895	SHA 68	Neuropeptide Y Receptor	GPCR/G Protein; Neuroscience
	SHA 68 是一种有效且选择性的神经肽 S 受体 (NPSR) 非肽拮抗剂，对 NPSR Asn107和 NPSR Ile107的IC50分别为 22.0 和 23.8 nM，具有有限的血脑屏障渗透能力和用于神经痛的活性。
T21611L	BWX 46 Acetate BWX 46 Acetate(172997-92-1 Free base)	Neuropeptide Y Receptor	GPCR/G Protein; Neuroscience
	BWX 46 Acetate 是一种有效的、高度选择性的神经肽 Y (NPY) 受体激动剂，IC50 为 0.5 nM。
TP1044L	Pancreatic Polypeptide, rat acetate	Neuropeptide Y Receptor	GPCR/G Protein; Neuroscience
	Pancreatic Polypeptide, rat acetate 是 NPY 受体的激动剂，对 NPYR4 具有高亲和力。
T23087	NPY 5RA972	Neuropeptide Y Receptor	GPCR/G Protein; Neuroscience
	NPY 5RA972 是一种神经肽 Y Y5 受体拮抗剂
T24121	GW438014A GW 438014 A,GW-438014-A	Neuropeptide Y Receptor	GPCR/G Protein; Neuroscience
	GW438014A 是一种有效且具有选择性的 NPY-Y5 受体拮抗剂。GW438014A 对食物摄入并减少肥胖啮齿动物的体重增加具有抑制作用。
TP1984L	[D-Trp34]-Neuropeptide Y Acetate [D-Trp34]-Neuropeptide Y Acetate (153549-84-9 Free base)	Neuropeptide Y Receptor	GPCR/G Protein; Neuroscience
	[D-Trp34]-Neuropeptide Y Acetate 是有效的、选择性的神经肽 Y (NPY) Y5 受体激动剂，在 NPY Y1，Y2，Y4 和 y6 受体上的效力较低。[D-Trp34]-Neuropeptide Y Acetate 可以显著增加大鼠的食物摄入量。
TP1137L	Pancreatic Polypeptide (human) acetate	Neuropeptide Y Receptor	GPCR/G Protein; Neuroscience
	Pancreatic Polypeptide (human) acetate 是一种 C 末端酰胺化的 36 个氨基酸肽，可作为神经肽 Y (NPY) Y4/Y5 受体激动剂。
TP1618L	PACAP-38 (31-38), human, mouse, rat acetate PACAP-38 (31-38), human, mouse, rat acetate(138764-85-9 Free base)	PACAP	GPCR/G Protein
	PACAP-38 (31-38), human, mouse, rat acetate 是 PAC1 受体的激活剂。PACAP-38 (31-38), human, mouse, rat acetate 对交感神经元 NPY 和儿茶酚胺的产生具有强效、有效和持续的刺激作用，可用于神经营养和神经保护研究。
T23287	S 25585	Others	Others
	neuropeptide Y (NPY) Y5 receptor antagonist
T70952	UR-MK299
	UR-MK299 is a NPY Y1 receptor antagonist.
T22935	LU AA33810	Others	Others
	neuropeptide Y (NPY) Y5 receptor antagonist
T10921	CYM 9484	Others	Others
	CYM 9484 is a selective and potent neuropeptide Y (NPY) Y2 receptor antagonist with IC50 value of 19 nM.
T71091	Y2-Antagonist-2
	Y2-Antagonist-2 is a novel, selective, soluble non-peptidic NPY Y2 receptor antagonist with enhanced CNS exposure.
T35599	Neuropeptide Y (3-36) (human, rat) (trifluoroacetate salt)
	Neuropeptide Y (NPY) (3-36) is a C-terminal fragment of NPY, a neuropeptide involved in controlling appetite, blood pressure, cardiac contractility, and intestinal secretion. NPY (3-36) is an endogenous peptide produced by cleavage of NPY by dipeptidyl peptidase 4 (DPP-4). It binds selectively to the NPY receptor Y2 (Ki = 0.41 nM in CHP 234 cells) over the Y1 receptor, where it does not bind at concentrations up to 1 μM. NPY (3-36) (0.1 nM) increases migration of human umbilical vein endothelial...
T69220	GW438014 free base
	GW438014A is a selective NPY-Y5 receptor antagonist.
T26800	BIBO3304 BIBO-3304,BIBO 3304
	BIBO3304 is a selective NPY Y1 receptor antagonist (IC50 values are 0.38 and 0.72 nM at human and rat receptors respectively). BIBO3304 inhibits NPY- and fasting-induced feeding in vivo following central administration.
T14572	BIIE-0246 AR-H 053591	Others	Others
	BIIE-0246 is a potent and highly selective non-peptide neuropeptide Y (NPY) Y2 receptor antagonist. With an IC50 of 15 nM.
T74654	Neuropeptide Y5 receptor ligand-1
	Neuropeptide Y5 receptor ligand-1 (compound 54)，一种咔唑衍生物，作为高效的神经肽 Y5 (NPY-5) 受体拮抗剂。
T75911	[D-Trp34]-Neuropeptide Y TFA
	[D-Trp34]-Neuropeptide Y TFA，一种高效且选择性的神经肽Y (NPY) Y5受体激动剂，其在NPY Y1、Y2、Y4及Y6受体上的活性显著低于Y5受体。该化合物能显著提高大鼠的食物摄入量。
T70061	CGP 71683 (free base)
	CGP 71683 (free base) is a potent and highly selective non-peptide antagonist of the NPY Y(5) receptor in the study of obesity.
T10540	BIBP3226 TFA	Others	Others
	BIBP3226 TFA is an effective and selective antagonist of neuropeptide Y Y1 (NPY Y1) and neuropeptide FF (NPFF) receptor (Kis: 1.1, 79, and 108 nM for rNPY Y1, hNPFF2, and rNPFF).
T36481	BIIE 0246 hydrochloride
	Potent, selective and competitive nonpeptide antagonist for the neuropeptide Y Y2 receptor (IC50 = 15 nM). Displays > 650-fold selectivity for NPY Y2 over Y1, Y4 and Y5 receptors. Active in vivo.
TP2022	GR231118 GR 231118
	Potent neuropeptide Y (NPY) Y1 receptor antagonist (pA2 = 10 and 10.5 at rY1 and hY1, receptors respectively). Also a potent and selective NPY Y4 receptor agonist (pEC50 values are 6.0, 8.6 and 6.1 for rY2, hY4 and rY5 receptors respectively). Suppresses
T36445	Neuropeptide Y (3-36) (human, rat)
	Neuropeptide Y (3-36) (human, rat) is a metabolite of neuropeptide Y (NPY) generated by dipeptidyl peptidase-4 (DPP4). Known as a selective Y2 receptor agonist, Neuropeptide Y (3-36) (human, rat) effectively reduces the release of norepinephrine via the Y2 receptor[1][2].
TP1137	Pancreatic Polypeptide, human Human pancreatic polypeptide
	Endogenous high affinity agonist for human NPY Y4 receptor (Ki = 0.056 nM). Believed to play an important role in the function of the gastrointestinal tract.
T76357	Neuropeptide Y (18-36) (porcine)
	Neuropeptide Y (18-36) (porcine) 是一种与Neuropeptide Y(NPY)心脏受体进行竞争性拮抗的化合物。该化合物通过浓度依赖的方式，抑制I-NPY与心室膜的结合，具有IC50值158 nM和Ki值140 nM。Neuropeptide Y (18-36) (porcine) 主要用于充血性心力衰竭的研究。
T37528	tBPC
	Positive allosteric modulator of neuropeptide Y receptor 4 (Y4R). Potentiates Y4R response to pancreatic polypeptide (PP), neuropeptide Y (NPY) and peptide YY (PYY) (EC50 values are 0.03, 0.4 and 0.5 nM respectively). Shows selectivity for Y4R over Y1R, Y2R and Y5R. Schubert et al (2017) Identification and characterization of the first selective Y4 receptor positive allosteric modulator. J.Med.Chem. 60 7605 PMID:28795803
T75730	[D-Arg25]-Neuropeptide Y (human)
	[D-Arg25]-Neuropeptide Y (human) ([D-Arg25] NPY) 是Y1受体的选择性激动剂。与阿尔茨海默病相关，该化合物能够保护老鼠皮质神经元免受淀粉样蛋白毒性的损害。
T41188	BIBP 3226 trifluoroacetate
	BIBP 3226 trifluoroacetate is a mixed non-peptide neuropeptide Y Y1(NPY Y1) and neuropeptide FF (NPFF) receptor antagonist (Kivalues are 1.1, 79, 108, > 1000, > 1000 and >1000 for rNPY Y1, hNPFF2, rNPFF, rNPY Y2, rNPY Y4and rNPY Y5respectively). Produces an anxiogenic-like effect in rats following i.c.v. administration.
T76355	Neuropeptide Y (3-36) (porcine)
	Neuropeptide Y (3-36) (porcine) 是一种针对 Y2 亚型的 NPY 受体的激动剂，同时也通过一种尚未明确的受体来调控大鼠的摄食行为。
TP1963	[cPP1-7,NPY19-23,Ala31,Aib32,Gln34]-hPancreatic Polypeptide cpp1-7-npy19-23-ala31-aib32-gln34-hpancreatic-polypeptide,[cPP1-7,NPY19-23,Ala31,Aib32,Gln34] - hPancreatic Polypeptide
	Potent, selective peptide agonist for the neuropeptide Y Y5 receptor (IC50 values for inhibition of NPY binding to human Y5, Y1, Y2 and Y4 receptors are 0.24, 530, > 500, and 51 nM respectively, Ki at Y5 = 0.1 - 0.15 nM). Stimulates food intake in vivo.
TP1044	Pancreatic Polypeptide, rat Rat pancreatic polypeptide
	Pancreatic Polypeptide, rat is an agonist of NPY receptor, with high affinity at NPYR4. Pancreatic polypeptide (PP) is a 36-amino acid, C-terminally amidated peptide, and is a member of the PP-fold peptide family. It is produced and secreted by the PP cel
TP1984	[D-Trp34]-Neuropeptide Y
	Potent neuropeptide Y (NPY) Y5 receptor agonist (pEC50 values are 7.82, 6.28, 6.44 and > 6 at rat Y5, Y4, Y1 and Y2 receptors respectively) that displays > 26-fold, > 1000-fold and > 1000-fold selectivity over Y1, Y2 and Y4 receptors respectively. Induces

化合物

NTNCB hydrochloride

Cat.No: T23094

Target: Others, Neuropeptide Y Receptor

Cat.No: T8963

Target: Neuropeptide Y Receptor

Cat.No: TQ0286

Target: Neuropeptide Y Receptor

[Leu31,Pro34]-Neuropeptide Y (porcine)

Cat.No: TP2206

Synonym: LEU 31, PRO34]-神经肽Y(猪)

Target: Neuropeptide Y Receptor

Galanin (1-16), mouse, porcine, rat

Cat.No: TP1380

Target: Neuropeptide Y Receptor

Cat.No: T17222

Synonym: 韦利贝特,S2367

Target: Neuropeptide Y Receptor

Cat.No: T10539

Target: Neuropeptide Y Receptor

CGP71683 hydrochloride

Cat.No: T5587

Synonym: CGP71683A,盐酸CGP71683

Target: Neuropeptide Y Receptor

Cat.No: T1997

Synonym: JNJ 31020028

Target: Neuropeptide Y Receptor

Cat.No: T5455

Synonym: SNAP37889,SNAP-37889

Target: Neuropeptide Y Receptor

Peptide YY (PYY) (3-36), human

Cat.No: TP1059

Synonym: Peptide YY (3-36)

Target: Neuropeptide Y Receptor

Cat.No: T8456

Target: Neuropeptide Y Receptor

Cat.No: T12895

Target: Neuropeptide Y Receptor

Cat.No: T21611L

Synonym: BWX 46 Acetate(172997-92-1 Free base)

Target: Neuropeptide Y Receptor

Pancreatic Polypeptide, rat acetate

Cat.No: TP1044L

Target: Neuropeptide Y Receptor

Cat.No: T23087

Target: Neuropeptide Y Receptor

Cat.No: T24121

Synonym: GW 438014 A,GW-438014-A

Target: Neuropeptide Y Receptor

[D-Trp34]-Neuropeptide Y Acetate

Cat.No: TP1984L

Synonym: [D-Trp34]-Neuropeptide Y Acetate (153549-84-9 Free base)

Target: Neuropeptide Y Receptor

Pancreatic Polypeptide (human) acetate

Cat.No: TP1137L

Target: Neuropeptide Y Receptor

PACAP-38 (31-38), human, mouse, rat acetate

Cat.No: TP1618L

Synonym: PACAP-38 (31-38), human, mouse, rat acetate(138764-85-9 Free base)

Target: PACAP

Cat.No: T23287

Target: Others

Cat.No: T70952

Cat.No: T22935

Target: Others

Cat.No: T10921

Target: Others

Y2-Antagonist-2

Cat.No: T71091

Neuropeptide Y (3-36) (human, rat) (trifluoroacetate salt)

Cat.No: T35599

GW438014 free base

Cat.No: T69220

Cat.No: T26800

Synonym: BIBO-3304,BIBO 3304

Cat.No: T14572

Synonym: AR-H 053591

Target: Others

Neuropeptide Y5 receptor ligand-1

Cat.No: T74654

[D-Trp34]-Neuropeptide Y TFA

Cat.No: T75911

CGP 71683 (free base)

Cat.No: T70061

Cat.No: T10540

Target: Others

BIIE 0246 hydrochloride

Cat.No: T36481

Cat.No: TP2022

Synonym: GR 231118

Neuropeptide Y (3-36) (human, rat)

Cat.No: T36445

Pancreatic Polypeptide, human

Cat.No: TP1137

Synonym: Human pancreatic polypeptide

Neuropeptide Y (18-36) (porcine)

Cat.No: T76357

Cat.No: T37528

[D-Arg25]-Neuropeptide Y (human)

Cat.No: T75730

BIBP 3226 trifluoroacetate

Cat.No: T41188

Neuropeptide Y (3-36) (porcine)

Cat.No: T76355

[cPP1-7,NPY19-23,Ala31,Aib32,Gln34]-hPancreatic Polypeptide

Cat.No: TP1963

Synonym: cpp1-7-npy19-23-ala31-aib32-gln34-hpancreatic-polypeptide,[cPP1-7,NPY19-23,Ala31,Aib32,Gln34] - hPancreatic Polypeptide

Pancreatic Polypeptide, rat

Cat.No: TP1044

Synonym: Rat pancreatic polypeptide

[D-Trp34]-Neuropeptide Y

Cat.No: TP1984

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